Nationwide Inventory of Risk Factors for Retinopathy of Prematurity in the Netherlands - 20/02/14
, Jacqueline U.M. Termote, PhD 2, Frank T. Kerkhoff, PhD 3, Laurentius J. van Rijn, PhD 4, Huibert J. Simonsz, PhD 5, Petronella G.M. Peer, PhD 6, Nicoline E. Schalij-Delfos, PhD 1Abstract |
Objectives |
To study the incidence and risk factors for retinopathy of prematurity (ROP) in the Netherlands.
Study design |
Prospective, approximating population-based study that included infants with gestational age (GA) <32 weeks and/or birth weight (BW) <1500 g born in 2009. Pediatricians and ophthalmologists of all hospitals involved in care for premature infants reported data that were matched with the national perinatal database for risk factor analysis.
Results |
Of 1380 infants, median GA 29.8 weeks (IQR 28.1-31.1) and median BW 1260 g (IQR 1020-1500), ROP developed in 21.9%. Logistic regression identified GA and BW as risk factors for ROP (P < .001). After adjustment for GA and BW, additional risk factors were inhaled nitric oxide (iNO; OR 2.6, 95% CI 1.1-6.2, P = .03), stay at a neonatal intensive care unit >28 days (OR 1.6, 95% CI 1.1-2.6, P = .03), and artificial ventilation >7 days (OR 1.6, 95% CI 1.1-2.5, P = .02). Prenatal glucocorticoids (OR 0.6, 95% CI 0.4-0.8, P < .001) and female sex (OR 0.7, 95% CI 0.5-0.99, P = .04) showed a lesser incidence of ROP. iNO remained significant after correction for all significant factors (OR 2.6, 95% CI 1.1-6.2, P = .03).
Conclusion |
In addition to established risk factors (GA, BW, stay at a neonatal intensive care unit >28 days, and artificial ventilation >7 days), treatment with iNO as risk factor for ROP is a novel finding.
Le texte complet de cet article est disponible en PDF.Keyword : BPD, BW, CLD, DOB, GA, IGF-1, iNO, LOS, NEDROP, NICU, ppm, ROP, VEGF
Plan
| Supported by an unrestricted grant from ODAS Foundation (Delft, The Netherlands). The authors declare no conflicts of interests. |
Vol 164 - N° 3
P. 494 - mars 2014 Retour au numéro
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