Insilico prediction of anticancer cyanobacterial drug from Nostoc - 18/02/14
Abstract |
The aim of the present study was to predict the anticancer drug from the members of the cyanobacteria. In silico molecular docking was carried out between the cyanobacterial drug, cryptophycin-F and different types of cancer target proteins. Molecular docking also helped to compare the commercial drug, cabazitaxel with cyanobacterial drug, cryptophycin-F. The energy values produced by the cryptophycin-F with various cancer receptor molecules were ranging from −259.14 to −330.01 while, cabazitaxel showed −228.18 to −385.32. From the above results, it is concluded that cabazitaxel and cryptophycin-F produced more or less similar docking energy with cancer receptor molecules. Therefore, cryptophycin-F, a cyanobacterial drug can be employed as an alternative drug for treating various cancers without any side effects.
Le texte complet de cet article est disponible en PDF.Keywords : Anticancer drug, Cabazitaxel, Cryptophycin-F, Nostoc, Hex, Insilico docking
Plan
Vol 4 - N° 1
P. 71-73 - janvier 2014 Retour au numéro
Article précédent
- Iridoid glucoside attenuates hyperglycemia-mediated oxidative stress and thyroid hormone function in streptozotocin–induced diabetic rats
- Ramalingam Sundaram, Palanivelu Shanthi, Panchanatham Sachdanandam
- Free-radical-scavenging activity and antioxidant effect of ascophyllan from marine brown algae Padina tetrastromatica
- S. Mohsin, R. Mahadevan, G. Muraleedhara Kurup
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?