Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid - 18/02/14

Doi : 10.1016/j.bionut.2013.09.007

Celso O. Rezende ^a, Caroline Rigotto ^b, Wiliam Caneschi ^a, Carlos A.M. Rezende ^a, Mireille Le Hyaric ^a, Mara R.C. Couri ^a, Cláudia M.O. Simões ^b, Mauro V. de Almeida ^a,^⁎
^a Departamento de Química, Universidade Federal de Juiz de Fora, Campus Martelos, 36036-330 Juiz de Fora, MG, Brazil
^b Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88.040-900 Florianópolis, SC, Brazil

^⁎Corresponding author. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil. Tel.: +55 32 21 023 310; fax: +55 32 21 023 310.

Abstract

Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound 8 (IC₅₀=177μM). Five compounds (7, 10, 11, 12 and 14) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound 10 (IC₅₀=15.2μM; SI=27.1).

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Keywords : Anti-HSV-1 activity, Antioxidant activity, Caffeic acid, Gallic acid, Quinic acid

Plan

Introduction

Materials and methods

Chemistry

Evaluation of DPPH radical scavenging activity

Time-dependent absorbance decay of DPPH []

Determination of antioxidant activity

Anti-HSV-1 activity

Results and discussion

Conclusion

Disclosure of interest

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Vol 4 - N° 1

P. 35-38 - janvier 2014 Retour au numéro

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Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid - 18/02/14

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