The quest for wholesome nutraceutical sources is all-time high as acute and chronic ailments threaten human health. In this regard, a Malvaceae family member Hibiscus sabdariffa (roselle) holds plentiful potential. This plant with worldwide distribution is a powerhouse of phytochemicals viz. polyphenolics, especially anthocyanins. The nutritional abundance imparts it antioxidant, hypocholesterolaemic, antiobesity, hypotensive, antidiabetic, immunomodulatory, anticancer, hepatoprotective, antimicrobial, renoprotective, diuretic and anti-urolithiatic properties. Though this plant has a long history of use across cultures, the recent scientific validations have augmented its status as a nutrition resource. Food industries have started incorporating their calyces into various products. In the near future, the elaboration of more fortified foods is expected. This review is expected to be contributory in its popularization by kindling consumer as well as research interest.