Molecular characteristics of MDR Mycobacterium tuberculosis strains isolated in Fujian, China - 12/02/14
Doi : 10.1016/j.tube.2013.03.004
Qiuyang Chen a, e, Yu Pang b, e, Qingfu Liang a, e, Shufang Lin a, Yufeng Wang b, Jian Lin a, Yong Zhao a, Shuzhen Wei a, Jinfeng Zheng a, ⁎ 
, Suhua Zheng c, d, ⁎
, Suhua Zheng c, d, ⁎ a Fujian Center for Disease Control and Prevention, Fujian, China
b National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
c Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
d Beijing Chest Hospital, Capital Medical University, Beijing, China
∗Corresponding author. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. Tel./fax: +86 10 6954 4491.∗∗Corresponding author. Tel.: +86 591 8767 7152; fax: +86 591 8343 1464.
Summary |
Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two “false-negative” results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium tuberculosis, MDR, Molecular characteristics
© 2013
Elsevier Ltd. Tous droits réservés.
Vol 94 - N° 2
P. 159-161 - mars 2014 Retour au numéro
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