Interpreting Laboratory Results in Transgender Patients on Hormone Therapy - 23/01/14
, Colleen S. Kraft, MD a, Deborah French, PhD b, Wuyang Ji b, Alan H.B. Wu, PhD b, c, Vin Tangpricha, MD, PhD d, Corinne R. Fantz, PhD aAbstract |
Background |
Clinical guidelines recommend laboratory monitoring of transgender persons on cross-sex hormone therapy, but gender-specific reference intervals leave clinicians with the dilemma of deciding what is “normal” for each patient. The goal of this study was to identify consistent changes in measurands with hormone therapy and determine which reference interval is appropriate.
Methods |
Laboratory data were abstracted from the medical records of 55 male-to-female patients on hormone therapy and compared with 20 male and 20 female nontransgender subjects.
Results |
Hemoglobin, hematocrit, and low-density lipoprotein resembled female values (P < .005), while alkaline phosphatase, potassium, and creatinine resembled male values (P < .05). Triglycerides were higher (P < .005) than either the male or female groups. The remainder of the measurands showed no differences.
Conclusions |
Use of correct reference intervals in interpreting laboratory results reduces the risk of testing-related diagnostic error. Preliminary data suggest that new reference intervals need to be established for transgender patients.
Le texte complet de cet article est disponible en PDF.Keywords : Hormone therapy, Reference range, Transgender
Plan
| Funding: None. |
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| Conflict of Interest: None. |
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| Authorship: The corresponding author, Tiffany K. Roberts PhD, DABCC, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. |
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| These studies were ethically approved by the Institutional Review Boards of Emory University (IRB#00048474) and the University of California, San Francisco (IRB#11-05468). |
Vol 127 - N° 2
P. 159-162 - février 2014 Retour au numéro
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