Initial evidence for sex-specific effects of early emotional abuse on affective processing in bipolar disorder - 20/01/14
, R. Proujansky a, A. Gilbert b, R.J. Braga b, K.E. Burdick aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Purpose |
This study investigates the effect of sex and childhood trauma on affective processing in bipolar disorder (BPD) patients.
Methods |
In a sample of fifty-six BPD patients, we administered the Childhood Trauma Questionnaire (CTQ), and the Iowa Gambling Task (IGT) and the Affective Go/No-Go (AGNG) to measure affective processing. Analysis of Variance (ANOVA) was used to evaluate the effect of sex and childhood trauma on IGT; Repeated-Measures ANOVAs to measure accuracy and bias measures across conditions on the AGNG.
Results |
In the context of childhood abuse, females evidenced a more conservative cognitive style than males by selecting fewer cards from the disadvantageous decks [F(1, 49)=14.218; P<0.001] and showed an improvement throughout the task, as noted in a normal learning curve [F(1.49)=4.385; P=0.041)]. For the AGNG, an interaction specific to the negative valence stimuli on response bias measures was found. Abused females scored higher (mean=8.38; SD=6.39) than abused males (mean=0.69; SD=1.19) [F(1.46)=6.348; P=0.015].
Conclusion |
Severity of childhood trauma was significantly different between sexes. In the context of a history of emotional abuse, male bipolar patients tended toward a more risk-taking behavior compared to female. Further investigations are needed to elucidate potential pathophysiological mechanisms underlying this interaction.
Le texte complet de cet article est disponible en PDF.Keywords : Childhood trauma, Affective processing, Bipolar disorder, Iowa Gambling Test, Affective Go/No-Go
Plan
Vol 29 - N° 1
P. 52-57 - janvier 2014 Retour au numéro
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