Serum endocan levels as a marker of disease activity in patients with Behçet disease - 16/01/14
Abstract |
Background |
Endocan is a novel human endothelial cell–specific molecule. The central role of leukocytes and endothelial dysfunction in the development of Behçet disease (BD) led us to hypothesize that endocan might be a marker of this disease.
Objective |
We investigated the relationship between serum levels of endocan and disease activity in patients with BD.
Methods |
In all, 33 patients (16 active, 17 inactive) with BD and 35 healthy persons were included in the study. Endocan and C-reactive protein were measured in all subjects.
Results |
Patients with BD had significantly higher serum endocan levels. Mean serum levels of endocan were 1.29 ± 0.60 ng/mL (range: 0.58-2.99) in patients with BD and 0.75 ± 0.16 ng/mL (range: 0.48-1.21) in control subjects (P < .001). In patients with BD, serum endocan levels correlated moderately but significantly with C-reactive protein, erythrocyte sedimentation rate, and disease activity. Receiver operating characteristic curve analysis suggested that the optimum endocan level cut-off point for patients with BD was 0.87 ng/mL, with a sensitivity and specificity of 75.8% and 80%, respectively (area under curve 0.835, 95% confidence interval 0.738-0.932).
Limitations |
The main limitation of our study is the relatively small sample size.
Conclusions |
Circulating endocan may be a marker of BD activity.
Le texte complet de cet article est disponible en PDF.Key words : Behçet disease, endocan, endothelium, inflammation, intercellular adhesion molecule, leukocyte function-associated antigen
Abbreviations used : AUC, BD, CRP, ESM, ESR, ICAM, LFA, ROC, VEGF
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 70 - N° 2
P. 291-296 - février 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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