PET-CT and diagnostic CT: The synergy of metabolic and morphological data in onco-haematology - 14/01/14
, F. Giammarile a, b, C. Tychyj-Pinel b, C. Houzard a, b, E. Decullier c, d, e, F. Chateau b, A.F. Manichon b, I. Orliaguet b, A.S. Michallet f, G. Salles c, f, P.J. Valette a, b, F. Réty b
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Abstract |
Purpose |
Our goal was to determine how interpreting diagnostic CT together with PET-CT could improve the assessment of morphology in onco-haematology.
Patients and methods |
Fifty-nine patients with aggressive lymphoma were retrospectively included. The diagnostic CT scan was interpreted by two radiologists, followed by a combined analysis of the CT and the PET-CT carried out by two specialists in metabolic and morphological imaging. The diagnostic performances were assessed in terms of sensitivity and specificity, then concordance and discordance rates (kappa) were studied.
Results |
A combined interpretation of CT and PET-CT showed better diagnostic performances than those of interpretations of CT only in the assessment of nodal sites (826 sites, sensitivity of 99% versus 85%, P<0.05), extranodal sites (649 sites, sensitivity of 88% versus 78%) and bone sites (one analysed per patient, sensitivity of 50% versus 27%). The combined interpretation also improved inter-observer agreement and led to an upgraded Ann Arbor staging in 15% of patients, with a change of treatment in 10%.
Conclusion |
Interpretation of diagnostic CT in onco-haematology can be improved by combining it with an assessment of PET-CT. The synergy between metabolic and morphological information leads to improved diagnostic capabilities and renders interpretations more reproducible.
Le texte complet de cet article est disponible en PDF.Keywords : Positron emission tomography, CT, Lymphoma, Haematology
Plan
Vol 95 - N° 1
P. 55-62 - janvier 2014 Retour au numéro
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