Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity - 01/01/14

Doi : 10.1016/S1472-9792(13)70015-5

Samuel S. Stew ^a,^b, Perla J. Martinez ^a, Larry S. Schlesinger ^c, Blanca I. Restrepo ^c,^⁎

^a UT Health Houston, School of Public Health at Brownsville, 80 Fort Brown, Brownsville, Texas 78520, USA

^b The Advisory Board Company, Austin, Texas, USA

^c Center for Microbial Interface Biology and Department of Microbial Infection and Immunity, 460W 12th Ave, The Ohio State University, Columbus, Ohio 43210, USA

^* Corresponding author at: 80 Fort Brown, SPH Bldg, Brownsville, Texas 78520, USA. Tel.: 956 882 5172; Fax: 956 882 5152

Résumé

The expression of monocyte surface markers was compared between tuberculosis patients with and without type 2 diabetes (DM2). DM2 was associated with increased CCR2 expression, which may restrain monocyte traffic to the lung. Other host factors associated with baseline monocyte changes were older age (associated with lower CD11b) and obesity (associated with higher RAGE). Given that DM2 patients are more likely to be older and obese, their monocytes are predicted to be altered in function in ways that affect their interaction with Mycobacterium tuberculosis.

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Keywords : Tuberculosis, Diabetes, Monocyte, Innate immunity, CCR2, CD11b, RAGE

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Introduction

Methods

Participant enrollment and characterization

Monocyte isolation and flow cytometry

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Vol 93 - N° S

P. S78-S82 - décembre 2013 Retour au numéro

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Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity - 01/01/14

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