Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study - 25/12/13
Abstract |
Background |
Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma.
Objective |
We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing.
Methods |
We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years.
Results |
Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing.
Conclusion |
Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.
Le texte complet de cet article est disponible en PDF.Key words : Anxiety, asthma, child, preschool, child development, cohort studies, depression, prospective studies, stress, psychological
Abbreviation used : OR
Plan
| The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, the Rotterdam Homecare Foundation, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR). The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam; Erasmus University, Rotterdam; and the Netherlands Organization for Health Research and Development. V. W. V. J. received an additional grant from The Netherlands Organization for Health Research and Development (ZonMw 90700303, 916.10159). L.D. is the recipient of a European Respiratory Society/Marie Curie Joint Research Fellowship, no. MC 1226-2009. The research leading to these results has received funding from the European Respiratory Society and the European Community's Seventh Framework Programme FP7/2007-2013–Marie Curie Actions under grant agreement RESPIRE, PCOFUND-GA-2008-229571 and from the seventh framework programme, project CHICOS (HEALTH-F2-2009-241504). This manuscript was written with the support of the European Child Cohort Network EUCCONET, a Research Networking Programme financed by the European Science Foundation. |
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| Disclosure of potential conflict of interest: L. Duijts has received a European Respiratory Society/Marie Curie Joint Research Fellowship, no. MC 1226-2009. The research leading to these results has received funding from the European Respiratory Society and the European Community's Seventh Framework Programme FP7/2007-2013–Marie Curie Actions under grant agreement RESPIRE, PCOFUND-GA-2008-229571 and from the seventh framework programme, project CHICOS (HEALTH-F2-2009-241504). The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 133 - N° 1
P. 59 - janvier 2014 Retour au numéro
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