Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases - 25/12/13
, Anne Lise Brantsæter, PhD c, Maria C. Magnus, MPH b, d, Margaretha Haugen, PhD c, Ronny Myhre, PhD e, Bo Jacobsson, MD, PhD e, f, Matthew P. Longnecker, MD, ScD b, Helle M. Meltzer, PhD c, Stephanie J. London, MD, DrPH bAbstract |
Background |
Whether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants.
Objectives |
We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study).
Methods |
We examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders.
Results |
Consumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months.
Conclusions |
In this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, asthma, eczema, microbiome, Norwegian Mother and Child Cohort Study, probiotics, rhinoconjunctivitis
Abbreviations used : BMI, FFQ, MJ, MoBa, RR
Plan
| The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health, the Norwegian Ministry of Education and Research, the National Institute of Environmental Health Sciences (contract N01-ES-75558) and the Division of Intramural Research (contract ZIA ES049019), the National Institute of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01), and the Norwegian Research Council/FUGE (grant 151918/S10). |
|
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 133 - N° 1
P. 165 - janvier 2014 Retour au numéro
Article précédent
- Allergen reference doses for precautionary labeling (VITAL 2.0): Clinical implications
- Katrina J. Allen, Benjamin C. Remington, Joseph L. Baumert, Rene W.R. Crevel, Geert F. Houben, Simon Brooke-Taylor, Astrid G. Kruizinga, Steve L. Taylor
- High-content cytometry and transcriptomic biomarker profiling of human B-cell activation
- Christian Hennig, Claudia Ilginus, Kaan Boztug, Julia Skokowa, Laszlo Marodi, Anna Szaflarska, Mareike Sass, Claudio Pignata, Sara Sebnem Kilic, Isabel Caragol, Ulrich Baumann, Christoph Klein, Karl Welte, Gesine Hansen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?