Three-Dimensional Reconstruction Identifies Misaligned Pulmonary Veins as Intrapulmonary Shunt Vessels in Alveolar Capillary Dysplasia - 18/12/13
Doi : 10.1016/j.jpeds.2013.08.035
Csaba Galambos, MD, PhD 1, 2, Sunder Sims-Lucas, PhD 3, Steven H. Abman, MD 2, 4
1 Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO
2 Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO
3 Division of Nephrology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA
4 Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO
Abstract |
Alveolar capillary dysplasia (ACD) with misalignment of pulmonary veins (MPV) is a lethal neonatal lung disease. Death from ACD/MPV is caused by hypoxia, but the role of the MPV is unknown. Using 3-dimensional reconstruction of ACD/MPV lung tissue, we report that the veins in MPV are intrapulmonary shunt vessels, and speculate that MPV contributes to the poor prognosis.
Le texte complet de cet article est disponible en PDF.Keyword : 3D, ACD, IPSV, MPV, PPHN
Plan
| Supported by the National Institutes of Health (HL085703 and HL68702 [both to S.A.]). The authors declare no conflicts of interest. |
© 2014
Mosby, Inc. Tous droits réservés.
Vol 164 - N° 1
P. 192-195 - janvier 2014 Retour au numéro
Article précédent
- Comparison of Frozen and Unfrozen Blood Spots for Gene Expression Studies
- Changshuai Wei, Qing Lu, Sok Kean Khoo, Madeleine Lenski, Raina N. Fichorova, Alan Leviton, Nigel Paneth
- Kikuchi Disease in Connecticut
- Henry M. Feder, Jinli Liu, William N. Rezuke
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?