Vitamin D, Race, and Risk for Anemia in Children - 18/12/13
, Michal L. Melamed, MD, MHS 2, Juhi Kumar, MD, MPH 3, Cindy N. Roy, PhD 4, Edgar R. Miller, PhD, MD 5, Susan L. Furth, MD, PhD 6, Jeffrey J. Fadrowski, MD, MHS 1Abstract |
Objective |
To examine the association between 25-hydroxyvitamin D [25(OH)D] deficiency and anemia in a cohort of otherwise-healthy children and to determine whether race modifies the association between 25(OH)D status and hemoglobin (Hgb).
Study design |
Cross-sectional study of 10 410 children and adolescents ages 1-21 years from the 2001-2006 National Health and Nutrition Examination Survey. Anemia was defined as Hgb less than the 5th percentile for age and sex based on National Health and Nutrition Examination Survey III (1988-1994) data.
Results |
Lower 25(OH)D levels were associated with increased risk for anemia; <30 ng/mL, adjusted OR 1.93, 95% CI 1.21-3.08, P = .006, and <20 ng/mL, OR 1.47, 95% CI 1.14-1.89, P = .004. In linear regression, small but significant increases in Hgb were noted in the upper quartiles of 25(OH)D compared with the lowest quartile (<20 ng/mL) in the full cohort. Results of race-stratified linear regression by 25(OH)D quartile in white children were similar to those observed in the full cohort, but in black children, an increase in Hgb in the upper 25(OH)D quartiles was only apparent compared with the lowest black race−specific quartile (<12 ng/mL).
Conclusion |
25(OH)D deficiency is associated with increased risk of anemia in healthy US children, but the 25(OH)D threshold levels for lower Hgb are lower in black children in comparison with white children.
Le texte complet de cet article est disponible en PDF.Keyword : 25(OH)D, BMI, CDC, CKD, CRP, ESA, GFR, Hgb, NHANES, TIBC
Plan
| M.A. was supported by the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK] (K23-DK-084116). M.M. was supported by NIDDK (K23-DK-078774), NIH (R01 DK087783), and the American Society of Nephrology (Carl W. Gottschalk Research Scholar grant). The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the National Center for Health Statistics, Centers for Disease Control and Prevention. The authors declare no conflicts of interest. |
Vol 164 - N° 1
P. 153 - janvier 2014 Retour au numéro
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