Outcomes and prognostic factors in superficial spreading melanoma - 02/12/13
Abstract |
Background |
Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM).
Methods |
A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used.
Results |
A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results.
Conclusions |
BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.
Le texte complet de cet article est disponible en PDF.Keywords : Superficial spreading melanoma, Sentinel lymph node biopsy melanoma, Lymphovascular invasion, Nonsentinel lymph node melanoma, Melanoma histology, Melanoma prognosis
Plan
| This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech. |
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| The authors declare no conflicts of interest. |
Vol 206 - N° 6
P. 861-868 - décembre 2013 Retour au numéro
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