Preterm Infant Linear Growth and Adiposity Gain: Trade-Offs for Later Weight Status and Intelligence Quotient - 23/11/13
Abstract |
Objective |
To examine trade-offs between cognitive outcome and overweight/obesity in preterm-born infants at school age and young adulthood in relation to weight gain and linear growth during infancy.
Study design |
We studied 945 participants in the Infant Health and Development Program, an 8-center study of preterm (≤37 weeks gestational age), low birth weight (≤2500 g) infants from birth to age 18 years. Adjusting for maternal and child factors in logistic regression, we estimated the odds of overweight/obesity (body mass index [BMI] ≥85th percentile at age 8 or ≥25 kg/m2 at age 18) and in separate models, low IQ (<85) per z-score changes in infant length and BMI from term to 4 months, from 4 to 12 months, and from 12 to 18 months.
Results |
More rapid linear growth from term to 4 months was associated with lower odds of IQ <85 at age 8 years (OR, 0.82; 95% CI, 0.70-0.96), but higher odds of overweight/obesity (OR, 1.27; 95% CI, 1.05-1.53). More rapid BMI gain in all 3 infant time intervals was also associated with higher odds of overweight/obesity, and BMI gain from 4-12 months was associated with lower odds of IQ <85 at age 8. Results at age 18 were similar.
Conclusion |
In these preterm, low birth weight infants born in the 1980s, faster linear growth soon after term was associated with better cognition, but also with a greater risk of overweight/obesity at age 8 years and 18 years. BMI gain over the entire 18 months after term was associated with later risk of overweight/obesity, with less evidence of a benefit for IQ.
Le texte complet de cet article est disponible en PDF.Keyword : BMI, IHDP, NICU, SGA
Plan
Supported by the National Institutes of Health (K23 DK083817, K24 HL68041, R01 HD27344), Robert Wood Johnson Foundation, Maternal and Child Health Bureau (039543, MCJ-060515, MCJ-360593), and Pew Charitable Trust (91-01142). The authors declare no conflicts of interest. |
Vol 163 - N° 6
P. 1564 - décembre 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?