Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma - 09/11/13

Doi : 10.1016/j.biopha.2013.04.004

Hong-Chun Liu ^a,^⁎ , Yi Zhang ^b, Xli-Lin Wang ^c, Wang-Sen Qin ^d, Yu-Han Liu ^e, Lan Zhang ^f, Chang-Lian Zhu ^g
^a Department of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
^b Department of Biotherapy Center of The First Affiliated Hospital & Department of Bioengineering, Zhengzhou University, Zhengzhou 450052, China
^c Zhengzhou University, Zhengzhou 450052, China
^d Department of Medical Laboratory, Henan Province People's Hospital, Zhengzhou 450052, China
^e Department of Medical Laboratory, The Fifth People's Hospital of Zhengzhou, Zhengzhou 450000, China
^f Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
^g Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China

^⁎Corresponding author.

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Abstract

Purpose

To explore the expression of TPX2 and its significance in esophageal squamous cell carcinoma (ESCC) tissue and approach relationship between the TPX2 and clinicopathological characteristic of esophageal squamous cell carcinoma.

Method

RT-PCR and immunohistochemical staining were used to compare the expression of TPX2 in 62 esophageal squamous cell carcinoma, 31 atypical hyperplasia and 62 normal esophageal mucosa.

Results

In ESCC, atypical hyperplasia and in normal mucous membrane tissues, the positive rate of TPX2 protein expression was 85.5% (53/62), 51.6% (16/31) and 4.8% (3/62); the positive rate of TPX2 mRNA expression was 65.5% (40/62), 35.5 (11/31) and 4.83% (3/62). The expression of TPX2 protein and mRNA were correlated with invasive depth and lymphatic metastasis of ESCC (P<0.01).

Conclusions

Overexpression of TPX2 may be risk factor of lymph node in esophageal carcinoma, and maybe a potential biomarker for early diagnosis and prognosis of esophageal squamous cell carcinoma.

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Keywords : TPX2, Esophageal squamous cell carcinoma, Immunohistochemical, RT-PCR

Plan

Introduction

Materials and methods

Materials

Methods

Results

Expression of TPX2 mRNA and protein in the normal mucous membrane, the cancer the atypical proliferation and the esophagus scale cancer organizes

Expression of TPX2 mRNA and protein and its correlation with clinical pathology in esophageal cancer

Discussion

Conclusion

Contributors

Disclosure of interest

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Vol 67 - N° 8

P. 751-755 - octobre 2013 Retour au numéro

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Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma - 09/11/13

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