Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway - 09/11/13
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Abstract |
Both Topoisomerase I and angiogenesis factors have caught pharmaceutical chemists’ attention in antitumor chemotherapy field. A series of indenoisoquinoline derivatives with high Top I inhibitory from our previous work were evaluated for their anti-angiogenesis property using classic in vitro and vivo models. The results demonstrated that all the compounds could significantly decrease the proliferation of endothelial cells in a concentration-dependent manner. Besides, compound 1 exerted marked inhibition of angiogenesis in vivo and in vitro models. The HIF signaling pathway in HUVECs was affected by compound 1 in a time-dependent manner. These data suggest that the tested compound 1 could serve as promising lead compound for further development and optimization.
Le texte complet de cet article est disponible en PDF.Keywords : Indenoisoquinoline derivatives, Anti-angiogenesis, HIF-1α
Plan
Vol 67 - N° 8
P. 715-722 - octobre 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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