Evaluation of the potential role of a new mutation in mabA in modifying the response of Mycobacterium tuberculosis to isoniazid - 07/11/13
Doi : 10.1016/j.tube.2013.07.003
María Alonso a, b, Miguel Martínez-Lirola c, 1, Juan José Palacios d, Ángela Menéndez d, Marta Herranz a, b, Susana Martínez d, Emilio Bouza a, b, Darío García-de-Viedma a, b, e, ⁎ 
a Servicio de Microbiología Clínica y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
b CIBER Enfermedades Respiratorias (CIBERES06/06/0058), Spain
c Complejo Hospitalario Torrecárdenas, Almería, Spain
d Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, Oviedo, Spain
e CEI Campus Moncloa, UCM–UPM, Madrid, Spain
∗Corresponding author. Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, C/ Dr Esquerdo, 46, 28007 Madrid, Spain. Fax: +34 91 5044906.
Summary |
A new mutation in mabA, Thr4Ile, was identified in a Mycobacterium tuberculosis isolate from a patient whose culture remained positive after treatment. The same mutation was found in another 5 patients infected by different strains. A putative role for this mutation in the process of diminishing susceptibility to isoniazid is evaluated.
Le texte complet de cet article est disponible en PDF.Keywords : mabA, Mutation, Isoniazid, Resistance
© 2013
Elsevier Ltd. Tous droits réservés.
Vol 93 - N° 6
P. 664-667 - novembre 2013 Retour au numéro
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