Efficacy and safety of interferon-gamma-targeted therapy in Crohn's disease: A systematic review and meta-analysis of randomized controlled trials - 30/10/13
, Daping Yang a, Bo Huang a, Bangquan An bBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Aims |
To evaluate the efficacy and safety of interferon-gamma-targeted therapy in Crohn's disease (CD).
Methods |
Keyword and MeSH searches of MEDLINE/PubMed, EMBASE, the Cochrane Database, Science Citation Index and the Chinese Biomedical Database, from the inception of each database to March 2012, were used to identify all available randomized controlled trials. Summary estimates of treatment effects and safety were produced with Review Manager, using relative risks (RR) of clinical response, clinical remission and adverse events rates.
Results |
Only three randomized controlled trials comparing anti-interferon-gamma therapy with placebo were qualified for the meta-analysis according to inclusion criteria. There were significant differences in clinical remission rates between groups (at week 6: RR=2.01, 95% confidence interval [CI]: 1.18–3.45; at week 8: RR=1.98, 95% CI: 1.17–3.33). There was also a significant difference in clinical response rates at week 8 (RR=1.60, 95% CI: 1.12–2.27). However, there was no statistically significant difference between anti-interferon-gamma therapy and placebo on adverse events rates (RR=0.98, 95% CI: 0.79–1.20).
Conclusions |
Anti-interferon-gamma therapy is safe and effective for treating active CD despite slow onset of action.
Le texte complet de cet article est disponible en PDF.Plan
Vol 37 - N° 5
P. 507-513 - novembre 2013 Retour au numéro
Article précédent
- Portal system thrombosis in puerperium: A case report and literature review
- Qi Zhao, Yonghui Liu, Yuan Li, Daliang Liu
- Management of antithrombotic agents for colonoscopic polypectomies in Israeli gastroenterologists relative to published guidelines
- Dan Carter, Marc Beer-Gabel, Rami Eliakim, Ben Novis, Benjamin Avidan, Eytan Bardan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?