Co-occurring Depression and Pain in Multiple Sclerosis - 27/10/13

Doi : 10.1016/j.pmr.2013.06.001

Kevin N. Alschuler, PhD ^⁎ , Dawn M. Ehde, PhD, Mark P. Jensen, PhD
Department of Rehabilitation Medicine, University of Washington School of Medicine, Box 358815, 1536 North 115th Street, Seattle, WA 98133, USA

^∗Corresponding author. Department of Rehabilitation Medicine, UW Medicine Multiple Sclerosis Center, University of Washington School of Medicine, Box 358815, 1536 North 115th Street, Seattle, WA 98133.

Résumé

Depression and pain are highly prevalent among individuals with multiple sclerosis, and they often co-occur. The purpose of this article is to summarize the literature and theory related to the comorbidity of pain and depression and describe how their presence can impact individuals with multiple sclerosis. Additionally, the article discusses how existing treatments of pain and depression could be adapted to address shared mechanisms and overcome barriers to treatment utilization.

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Keywords : Depression, Pain, Multiple sclerosis

Plan

Key points

Introduction

Prevalence of pain, depression, and their comorbidity

Amplifying effects of pain and depression on one another

Overlapping impact of pain and depression on functioning and quality of life

Impact on treatment utilization and effectiveness

Interventions for comorbid pain and depression

Utilization of and access to interventions for comorbid pain and depression

Innovative approaches to the management of comorbid depression and pain

Future directions for research and clinical interventions

Sources of support: The contents of this article were developed under grants from: (1) the Institutes of Health, National Institute of Child Health and Human Development, National Center for Medical Rehabilitation Research (grant number R01HD057916); (2) the National Multiple Sclerosis Society (grant number MB 0008); and (3) the Department of Education (grant number H133B080025). The article does not necessarily represent the policy of the Department of Education, and you should not assume endorsement by the federal government.