Au cours des dernières années, le Wisconsin Card Sorting Test (WCST) a suscité une attention considérable dans le cadre des recherches sur la schizophrénie. Une performance déficitaire de patients schizophrènes dans cette tâche a maintes fois été rapportée. De tels résultats sont compatibles avec l'hypothèse d'une dysfonction affectant les régions frontales chez le patient schizophrène <sup>[1ANDREASEN NC, EHRHARDT JC, SWAYZE VW et al. Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. Arch Gen Psychiatry 1990 ; 47 : 35-44.

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In recent years, there has been a sustained interest in the so-called « frontal hypothesis » of schizophrenia : the idea that clinical symptoms and cognitive deficits characteristic of schizophrenia might be explained by defective function of the frontal lobes. Several studies have attempted to test this hypothesis by examining the performance of schizophrenic subjects on the Wisconsin Card Sorting Test (WCST), a neuropsychological evaluation widely believed to reflect the functional capacity of frontal lobes. A typical finding is that schizophrenic patients demonstrate a tendency to perseverate in producing an inappropriate response in spite of negative feedback. This perseverative tendency resembles the perseveration often seen in patients with frontal brain damage. This article proposes a critical examination of the available evidence linking frontal deficits with schizophrenia via the WCST. As we will show, in most of these studies, only a relatively small number of the available measures on the WCST are made, and consequently many interesting cognitive capacities in schizophrenic subjects have not been adequately examined with this test. These « non-classical » measures will be described and critically examined with respect to their pertinence for further work on schizophrenic subjects. Of particular interest are the « failure to maintain set », which measures cognitive instability, « conceptual responses », which can indicate a certain conceptual capacity even in subjects who show perseveration, and « learning to learn », which can demonstrate a capacity to profit from experience on the test. A second objective will be to critically examine the evidence concerning the capacity of schizophrenic patients to improve their performance on the WCST. To the extent that performance on the WCST reflects the functional level of cognitive capacities important for everyday life, any capacity in schizophrenic patients to improve their performance could have important implications for therapeutic intervention and re-education.