Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial - 17/08/13
Abstract |
Background |
Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies.
Objective |
We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema.
Methods |
This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded.
Results |
Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57% women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9%) and Nd:YAG (2.5%), but varied by treatment type, with PDL reducing facial redness 6.4% more from baseline than Nd:YAG (P = .0199; 95% confidence interval −11.6 to −1.2). Pain varied (P = .0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52% as a result of PDL, and 34% as a result of Nd:YAG (P = .031; 95% confidence interval −34.6 to −1.94). No serious adverse events were observed.
Limitations |
Lasers settings are not standardized across devices.
Conclusion |
Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful.
Le texte complet de cet article est disponible en PDF.Key words : comparative effectiveness research, dye, erythema, lasers, rosacea
Abbreviations used : CI, IPL, Nd:YAG, PDL
Plan
Funded by the Northwestern University Department of Dermatology. |
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Conflicts of interest: None declared. |
Vol 69 - N° 3
P. 438-443 - septembre 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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