Cognitive Outcome in Adolescents and Young Adults after Repeat Courses of Antenatal Corticosteroids - 23/07/13
Abstract |
Objective |
To investigate whether repeat courses of antenatal corticosteroids have long-term effects on cognitive and psychological functioning.
Study design |
In a prospective cohort study, 58 adolescents and young adults (36 males) who had been exposed to 2-9 weekly courses of betamethasone in utero were assessed with neuropsychological tests and behavior self-reports. Unexposed subjects (n = 44, 25 males) matched for age, sex, and gestational age at birth served as a comparison group. In addition, individuals exposed in utero to a single course (n = 25, 14 males) were included for dose-response analysis. Group differences were investigated using multilevel linear modeling.
Results |
Mean scores obtained in 2 measures of attention and speed were significantly lower in subjects exposed to 2 or more antenatal corticosteroids courses (Symbol Search, P = .009; Digit Span Forward, P = .02), but these were not dose-dependent. Exposure to repeat courses of antenatal corticosteroids was not associated with general deficits in higher cognitive functions, self-reported attention, adaptability, or overall psychological function.
Conclusions |
Although this study indicates that repeat exposure to antenatal corticosteroids may have an impact on aspects of executive functioning, it does not provide support for the prevailing concern that such fetal exposure will have a major adverse impact on cognitive functions and psychological health later in life.
Le texte complet de cet article est disponible en PDF.Keyword : WAIS, WISC
Plan
| Supported by Karolinska Institutet, Faculty of Social Sciences at Stockholm University, Stockholm County Council, the Swedish Order of Freemasons, the Swedish Research Council, and Foundation Olle Engkvist Byggmästare. The sponsors had no role in the design of the study; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. The authors declare no conflicts of interest. |
Vol 163 - N° 2
P. 441 - août 2013 Retour au numéro
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