1033 – Restless legs syndrome induced by the combined use of quetiapine and venlafaxine - 09/07/13
Résumé |
Introduction |
Restless legs syndrome (RLS) is a sensorimotor disorder characterized of an urge to move the legs during periods of rest or inactivity, such as lying or sitting.
Objectives |
Drug-induced RLS, still remains an under- or misdiagnosed condition.
Aims |
We present a case of a female patient, who received a combination of low dose of quetiapine in addition to venlafaxine and manifested RLS.
Methods |
Our patient was admitted because of a mixed episode of bipolar II disorder. At admission she was under valproic (1.5gr/QD, plasma levels: 79mg/litre), topiramate (100mg/QD) and venlafaxine (300mg/BID). Quetiapine 150mg/QD was started at bed time and within 48 hours the patient showed RLS. The physical, neurological and laboratory examination was normal.
Results |
The tapering of venlafaxine resulted in the elimination of RLS within 48 hours. After discharge the patient remained in a normothymic state, without RLS, taking valproate 1,5gr/QD, topiramate 100mg/QD and quetiapine 150mg/QD. After 6 months, because of depression, quetiapine was reduced to 100mg/QD and venlafaxine 75mh/QD was added. The previously described RLS symptoms emerged again within 48 hours. This time the tapering of quetiapine and its substitution by olanzapine 10mg/QD resulted in a prompt and complete elimination of RLS symptoms.
Conclusions |
Neither quetiapine alone, nor venlafaxine alone induced RLS to our patient. Clinicians should not overlook the possibility a RLS to be induced by quetiapine-vanlafaxine combination. The removal of one of the two drugs might be beneficial in the RLS's successful treatment.
Le texte complet de cet article est disponible en PDF.Vol 28 - N° S1
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