2860 – Reappraisal mediates the link between 5-HTTLPR and social anxiety symptoms - 09/07/13
Résumé |
Mounting evidence suggests that social anxiety symptoms are related to
(1) | polymorphisms in the serotonin transporter gene promoter region (5-HTTLPR) and |
(2) | reduced use of adaptive forms of emotion regulation such as reappraisal. |
It is not known, however, whether reappraisal mediates the link between 5-HTTLPR and social anxiety. Participants to this study were unselected community volunteers, all Caucasians from a circumscribed geographical area. They were genetically tested for 5-HTTLPR status, and self-report measures of social anxiety symptoms and reappraisal use were obtained. The results indicated that participants with one or two low-expressing alleles displayed increased social anxiety symptoms and reduced levels of cognitive reappraisal. Cognitive reappraisal significantly mediated the influence of 5-HTTLPR on social anxiety symptoms, and this effect was evident on two different measures of reappraisal. Therefore, this study shows that cognitive reappraisal is a major intermediate phenotype of the social anxiety spectrum. Our correlational results suggest that individuals with low-expressing 5-HTTLPR genotypes may benefit the most from cognitive-behavioral psychotherapy because they do not appear to engage as frequently as others in reappraisal.
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Vol 28 - N° S1
P. 1 - 2013 Retour au numéro
Article précédent
- 2859 – Depression and diabetes comorbidity: prevalence and clinical features
- S. El-Hechmi, Y. Zgueb, R. Jomli, S. Ouanes, F. Nacef, Z. Turki
- 2862 – Reason for psychiatric consultation in the elderly
- R. Ennaoui, R. Jomli, A. Ouertani, Y. Zgueb, F. Nacef
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