747 – Brain-derived neurotrophic factor and b-cell lymphoma leukemia-2 plasma levels in patients with subsyndromal symptomatic depression - 09/07/13
Résumé |
Objective |
To explore the relationship between brain-derived neurotrophic factor (BDNF) and B-cell lymphoma Leukemia-2 (Bcl-2) plasma levels in subsyndromal symptomatic depression (SSD) patients.
Methods |
In this case-control study, Enzyme-Linked Immunosorbnent Assay (ELISA) method was used to analysed the differences of BDNF plasma levels between SSD group (n=42) and healthy controls (n=51). At the same time Hamilton Depression Rating Scale-17(HAMD17) were assessed the patients'severity.
Result |
There were significant difference of BDNF plasma levels between SSD group (medium 2.97ng/ml)and healthy group (medium 3.71ng/ml, z=-2.94, P0.003). Furthermore, BDNF plasma levels in SSD patients were associated with Hamilton score (r -0.53, P <0.001). Plasma Bcl-2 levels were not different between SSD group (medium 4951U/ml) and health controls (medium 5574U/ml) (z =-1.71, P =0.09); and plasma Bcl-2 levels in SSD group were not associated with Hamilton score (r-0.10, P0.34).
Conclusion |
The study suggested that the decreased BDNF plasma levels were related with the pathophysiology of SSD and it might reflect the severity of disorder.
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Vol 28 - N° S1
P. 1 - 2013 Retour au numéro
Article précédent
- 746 – Insight as a mediator between stigma and depression in schizophrenia
- D. Krupchanka, M. Katliar
- 749 – The factors associated with occurrence of suicidal risk after treatment of ssri in bipolar disorder with their first depressive episode
- Z. Li, Y. Guan, Y. Fang
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