1055 – Effect of lurasidone on weight and metabolic parameters: a comprehensive analysis of short- and long-term trials in schizophrenia - 09/07/13
Résumé |
Introduction |
Patients with schizophrenia are at high risk for diabetes, dyslipidemia, hypertension, and obesity, which can be exacerbated by some atypical antipsychotics.
Objectives |
To evaluate the effect of lurasidone on weight and metabolic parameters.
Aims |
To establish the cardiometabolic safety of lurasidone.
Methods |
Short-term data were pooled from seven, double-blind, 6-week studies of subjects with acute exacerbation of schizophrenia treated with lurasidone 20-160mg/day (N=1508); haloperidol 10mg/day (N=72); olanzapine 15mg/day (N=122); risperidone 4mg/day (N=65); quetiapine XR 600mg/day (N=119) or placebo (N=708). Long-term data (6-22 months) were pooled from patients treated with lurasidone 40-120mg/day (flexibly dosed).
Results |
Proportions of patients experiencing ≥7% weight gain during short-term treatment were: lurasidone 4.8%, haloperidol 4.2%, olanzapine 34.4%, risperidone 6.2%, quetiapine XR 15.3%, and placebo 3.3%. Median lipid changes were: triglycerides (mg/dL), lurasidone -4.0, haloperidol -3.0, olanzapine +25.0, risperidone +4.0, quetiapine XR +9.5, and placebo -6.0; total cholesterol (mg/dL), lurasidone -5.0, haloperidol -8.0, olanzapine +9.0, risperidone +6.5, quetiapine XR +6.0, and placebo -5.0; trends were similar for LDL. Median changes in glucose (mg/dL) were similar for lurasidone (0.0) and placebo (0.0), and higher for haloperidol (+2.0), olanzapine (+4.0), risperidone (+3.0), and quetiapine XR (+3.0). Minimal-to-no changes in HbA1c were observed. With long-term lurasidone treatment, mean weight change after 12-month exposure was -0.73 kg and median metabolic changes were: -2.0mg/dL for total cholesterol and -5.0mg/dL for triglycerides.
Conclusions |
Short- and long-term treatment with lurasidone showed minimal changes in weight and decrease in mean total and LDL cholesterol and triglycerides.
Le texte complet de cet article est disponible en PDF.Vol 28 - N° S1
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