Role of Cells and Mediators in Exercise-Induced Bronchoconstriction - 04/07/13
, William A. Altemeier, MD a, Moira L. Aitken, MD a, William R. Henderson, MD bRésumé |
A susceptible group of subjects with asthma develops airflow obstruction in response to the transfer of water out of the airways during exercise. The transfer of water or the challenge with a hypertonic solution serves as a strong stimulus to the airway epithelium. Susceptible subjects have epithelial shedding into the airway lumen, and airway inflammation that leads to the overproduction of leukotrienes and other eicosanoids following exercise challenge. The sensory nerves of the airways may serve as a critical link that mediates the effect of eicosanoids, leading to bronchoconstriction and mucus production in response to exercise challenge.
Le texte complet de cet article est disponible en PDF.Keywords : Asthma, Eicosanoid, Eosinophil, Exercise-induced bronchoconstriction, Leukotriene, Mast cell, Phospholipase, Prostaglandin
Plan
| Funding: Supported by National Institutes of Health grant HL089215. |
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| Disclosures: T.S. Hallstrand has received research grants from the NIH, American Lung Association, has served as a consultant for Amgen and TEVA pharmaceuticals, and has received lecture fees from Merck & Co. W.R. Henderson has served on advisory boards for Gilead Sciences, has received lecture fees from Merck & Co., and has received industry-sponsored grants from Genentech and Gilead Sciences. W.A. Altemeier and M.L. Aitken have no conflicts of interest. |
Vol 33 - N° 3
P. 313-328 - août 2013 Retour au numéro
Article précédent
- Pathogenesis of Exercise-Induced Bronchoconstriction
- Pascale Kippelen, Sandra D. Anderson
- Refractoriness to Exercise Challenge : A Review of the Mechanisms Old and New
- Johan Larsson, Sandra D. Anderson, Sven-Erik Dahlén, Barbro Dahlén
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