Botulinum toxin (BoNTA) has become the modern generation’s treatment of choice for facial aging. Advanced uses of neurotoxin have treated specific areas of the face, in addition to the glabella, which is the only site for injection approved by the Food and Drug Administration. This article suggests that BoNTA has replaced surgical procedures that treat oral commissures, mild brow ptosis and brow asymmetries, and hypertrophic orbicularis oculi muscles. It is becoming increasingly used for lip asymmetry, platysmal banding, and necklift, although it has not replaced traditional procedures for the correction of these areas.