The Role of Toll-like Receptor (TLR) 2 and 9 in Renal Ischemia and Reperfusion Injury - 31/05/13
Reprint requests: Guanxin Gao, Ph.D., People’s Hospital of Inner Mongolia A.R., 26 Zhaowuda Rd, Hohhot, Inner Mongolia 010017, P. R. China.Abstract |
Objective |
To determine the involvement of Toll-like receptor (TLR) 2, TLR9, and TLR2+9 in renal ischemia/reperfusion (I/R) injury.
Methods |
Mice with gene knock-out of TLR2, TLR9, and TLR2+9 underwent renal I/R injury. Tubular damage, expression of proinflammatory cytokines and chemokines, and kidney dysfunction were evaluated on different days after reperfusion.
Results |
Mice deficient in TLR2, but not TLR9, were protected from renal I/R injury with less tubular damage, decreased cytokine production, and lower serum creatinine and urea levels than wild-type mice. TLR2+9 double-deficiency did not have an additional effect on tissue injury compared with TLR2 deficiency alone.
Conclusion |
These results suggest that activation of TLR2 signaling contributes to the pathogenesis of renal I/R injury, whereas TLR9 may be redundant for the development of this injury.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
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| Funding Support: This study was supported by the Fund for the Natural Science Foundation of Inner Mongolia Autonomous Region (2011BS1106). |
Vol 81 - N° 6
P. 1379.e15-1379.e20 - juin 2013 Retour au numéro
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