N-Terminal Pro-Brain Natriuretic Peptide and Risk of Coronary Artery Lesions and Resistance to Intravenous Immunoglobulin in Kawasaki Disease - 23/05/13
, Takahisa Kimata, MD, Kenji Mine, MD, Takamichi Uchiyama, MD, Shoji Tsuji, MD, Kazunari Kaneko, MD
Reprint requests: Ken Yoshimura, MD, Department of Pediatrics, Kansai Medical University, 2-3-1 Shin-machi, Hirakata-shi, Osaka 573-1191, Japan.Abstract |
Objective |
To determine whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) can be a useful marker not only to identify the patients with Kawasaki disease (KD) who are at a higher risk of developing coronary artery lesions (CAL), and predict resistance to intravenous immunoglobulin (IVIG).
Study design |
We enrolled 80 patients with the acute phase of KD at a single center. The demographic, clinical, and laboratory data were prospectively collected.
Results |
Nineteen of the 80 patients developed CAL, despite IVIG administration. They had a significantly higher serum NT-proBNP level in comparison with the patients without CAL. The NT-proBNP cut-off value of 1300 pg/mL yielded a sensitivity of 95% and a specificity of 85% for predicting CAL. However, 17 of the 80 patients were IVIG non-responders. They also had a significantly higher serum NT-proBNP level in comparison with the IVIG responders. The NT-proBNP cut-off value of 800 pg/mL yielded a sensitivity of 71% and a specificity of 62% for predicting IVIG non-responders.
Conclusions |
The serum NT-proBNP level is increased in children with KD with CAL and IVIG resistance. It may be useful to predict CAL and IVIG resistance in KD.
Le texte complet de cet article est disponible en PDF.Keyword : BNP, CAL, CRP, IVIG, KD, LMT, NT-proBNP, pLAD, pRCA, WBC
Plan
| Funded by the Mami Mizutani Foundation. The authors declare no conflicts of interest. |
Vol 162 - N° 6
P. 1205-1209 - juin 2013 Retour au numéro
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