Lymph node invasion might have more prognostic impact than R status in advanced esophageal adenocarcinoma - 16/05/13
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Abstract |
Background |
Advanced esophageal adenocarcinomas are associated with 5-year survival rates ranging from 14% to 35%. Nodal status and tumor clearance are the main prognostic factors. However, their respective prognostic values have not been compared to date.
Methods |
Seventy consecutive patients with stage T3 adenocarcinomas of the esophagus or gastric cardia were retrospectively assessed. Neoadjuvant therapy was indicated in all cases. Prognostic values of R0 resection and nodal status were evaluated using univariate and multivariate analyses.
Results |
Neoadjuvant therapy was achieved in 62 patients, 41 with radiochemotherapy and 21 with perioperative chemotherapy. Transthoracic esophagectomy and transhiatal esophagectomy were performed in 54 and 15 patients, respectively. Clavien-Dindo grade III or IV complications occurred in 16 patients (23%). Two patients died in the hospital (3%). In univariate and multivariate analyses, nodal status was the main independent factor predicting overall survival; tumor clearance (R0 or R1) had less prognostic impact and was not statistically significant. Furthermore, R1 resection was a prognostic indicator for metastatic recurrence.
Conclusions |
These results indicate that nodal status has more prognostic impact than R status in stage T3 adenocarcinomas of the esophagus or gastric cardia. Thus, local control in R1 patients by postoperative radiotherapy is not justified.
Le texte complet de cet article est disponible en PDF.Keywords : Esophagus, Cancer, Adenocarcinoma, Lymph node invasion, Radicality, Prognosis
Plan
The authors declare no conflicts of interest. |
Vol 205 - N° 6
P. 711-717 - juin 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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