Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics - 04/05/13

Doi : 10.1016/j.neurad.2012.04.001

Peigang Lu ^a,^{^{1
These authors contributed equally to this work and should be considered co-first authors.},}^{^{2
Tel.: +86 531 51 66 58 28.}} , Linping Shi ^b,^c,^{^{1
These authors contributed equally to this work and should be considered co-first authors.},}^{^{3
Tel.: +86 159 72 18 40 88.}} , Hanjian Du ^a,^{^{4
Tel.: +86 187 64 16 61 31.}} , Bing Xie ^c,^{^{5
Tel.: +86 23 65 48 63 55.}} , Changying Li ^c,^{^{6
Tel.: +86 132 28 68 74 85.}} , Sha Li ^d , Ting Liu ^e , Hua Feng ^f,^{^{7
Tel.: +86 65 46 30 26.}} , Jian Wang ^c,^⁎
^a Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, PR China
^b Department of Radiology, Hubei Provincial Corps Hospital, Chinese People’s Armed Police Forces, Wuhan 430061, China
^c Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
^d Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
^e Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing 400038, China
^f Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Corresponding author. Tel.: +86 23 68 75 44 19.

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Summary

Background and purpose

The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis.

Methods

Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).

Results

Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected).

Conclusion

The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.

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Keywords : Primary open-angle glaucoma, White matter, DTI, Tract-based spatial statistics

Plan

Introduction

Materials and methods

Subjects

Data acquisition

Preprocessing of raw DTI data

TBSS analysis

Results

Discussion

Disclosure of interest

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Vol 40 - N° 2

P. 89-93 - mai 2013 Retour au numéro

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Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics - 04/05/13

Summary

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Results

Conclusion

Plan

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