Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics - 04/05/13
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Summary |
Background and purpose |
The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis.
Methods |
Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).
Results |
Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected).
Conclusion |
The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
Le texte complet de cet article est disponible en PDF.Keywords : Primary open-angle glaucoma, White matter, DTI, Tract-based spatial statistics
Plan
Vol 40 - N° 2
P. 89-93 - mai 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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