NSAID Single-Drug–Induced Reactions - 30/04/13

Doi : 10.1016/j.iac.2012.12.002

Katharine M. Woessner, MD ^a,^⁎ , Mariana Castells, MD ^b
^a Scripps Allergy and Immunology Fellowship Program, Division of Allergy and Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, CA 92130, USA
^b Allergy and Clinical Immunology Training Program, Brigham and Women’s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 626D, Boston, MA 02115, USA

Corresponding author.

Résumé

Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been implicated in a variety of drug-induced reactions that are proved as or suspected of being mediated through a host immune response. Single-drug–induced reactions are the hallmark of these types of reactions. The types of single-drug–induced reactions are the confluence of 2 variables, the structure of the drug and the specific types of immune responses. This article identifies reactions patterns and the NSAIDs most likely to elicit each immune response.

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Keywords : Nonsteroidal anti-inflammatory drugs (NSAIDs), Adverse drug reactions (ADRs), Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN), Drug rash with eosinophilia and systemic symptoms (DRESS), Acute generalized erythematous pustulosis (AGEP)