The prevalence of atopic triad in children with physician-confirmed atopic dermatitis - 24/04/13
Reprint requests: David J. Margolis, MD, PhD, University of Pennsylvania School of Medicine, 815 Blockley Hall, 423 Guardian Dr, Philadelphia PA 19104.Abstract |
Background |
Atopic dermatitis (AD) is often associated with comorbidities such as allergic rhinitis and asthma.
Objective |
We sought to describe the frequency of these comorbidities in children with AD.
Methods |
We conducted a cross-sectional study of the first 2270 children with physician-confirmed AD enrolled in a large postmarketing cohort. All were queried for information on comorbidities using a questionnaire from the International Study of Asthma and Allergies in Childhood.
Results |
In all, 71.3% reported at least one additional form of atopy (symptoms of asthma or allergic rhinitis). A total of 33.3% reported only symptoms of asthma or allergic rhinitis whereas 38.0% reported symptoms of asthma and allergic rhinitis. By age 3 years, nearly 66% reported at least one additional form of atopy. A statistically significant trend toward poorer disease control was observed for those with additional atopic illnesses (P < .001).
Limitations |
This is a cross-sectional study.
Conclusion |
Individuals with AD exhibit a predisposition to additional atopic illnesses by age 3 years and in turn the presence of these illnesses correlates with poor disease control.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AD, CI, FDA, ISAAC, OR, PEER
Plan
| Supported by an unrestricted grant from Novartis to Trustees of the University of Pennsylvania to conduct the design, data management, and analysis aspects of the PEER study. |
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| Disclosure: Ms Leclerc is an employee of Novartis. Dr Margolis has a consulting relationship with Astellas Pharmaceuticals but not with Novartis. Drs Kapoor, Menon, and Bilker, and Mr Hoffstad, have no conflicts of interest to declare. |
Vol 58 - N° 1
P. 68-73 - janvier 2008 Retour au numéro
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