Intraductal thermal injury using a heat probe and radiofrequency ablation electrode in a swine model of biliary stenosis - 16/04/13
, Su-A Kim a, Jong Hak Choi a, Kwang Min Kim a, Jong Kyun Lee a, Kyu Taek Lee a, Yoon-La Choi b
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Summary |
Background and objective |
An animal model for bile duct stenosis using intraductal thermal injury has not yet been established. The aims of the current study were to develop biliary stenosis in a swine model by inducing intraductal thermal injury using a heat probe or radiofrequency ablation electrode and to investigate an effective and safe energy dose.
Methods |
Intraluminal thermal injury was applied to the common bile duct with a heat probe in three swines and a radiofrequency ablation electrode in the other three swines by either endoscopic retrograde cholangiography or open laparotomy. Cholangiography and histologic evaluation of common bile duct were taken 2 weeks after thermal injury.
Results |
Thermal injury with a heat probe at 25J for 40seconds produced a stricture in all three animals. Application of a radiofrequency ablation electrode produced a stricture in two of three animals. An energy dose of 40W at 80°C for 30seconds produced biliary stenosis without any complications initially and 2 weeks after thermal injury.
Conclusions |
The application of a heat probe and a radiofrequency ablation electrode for intraductal thermal injury resulted in a reproducible animal model of biliary stenosis.
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Vol 37 - N° 2
P. 159-165 - avril 2013 Retour au numéro
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