The stratigraphic and paleoenvironmental context of the Verduno fossil vertebrate locality is discussed herein based on its rodent record. The Verduno section crops out in the southern part of the Tertiary Piedmont Basin (TPB), and can be included in the Messinian post-evaporitic Cassano Spinola Fm., chronologically corresponding to the so-called Lago-Mare event. Rodents are represented by a relatively rich assemblage. Murids are by far the most diverse and abundant, with at least four taxa, including the common Centralomys benericettii and Paraethomys meini, and the rare Apodemus gudrunae and Occitanomys sp. Cricetids are represented by a single species, Apocricetus cf. A. barrierei. Muscardinus aff. M. vireti appears to be the only glirid present at Verduno. The Verduno rodent assemblage shares some taxa with other Messinian post-evaporitic localities from Italy bearing continental vertebrate remains, such as Brisighella (central Italy) and Moncucco Torinese (NW Italy) (e.g., C. benericettii, P. meini) and, possibly, with Ciabòt Cagna (NW Italy). However, the general structure of these four Messinian assemblages displays substantial differences, which may reflect different palaeoenvironmental conditions.