Antibody response to Mycobacterium tuberculosis p27-PPE36 antigen in sera of pulmonary tuberculosis patients - 18/03/13
Corresponding author. UBO, IUT de Quimper, 2, rue de l’Université, 29334 Quimper, France. Tel.: +33 (0) 1 69 15 48 29.Summary |
We have expressed, characterized and studied the immune response of mice against the Mycobacterium tuberculosis PPE36 protein. This protein encoded by the gene Rv2108 is a 27-kDa cell-wall associated protein. Here, we compare the antibody isotypes distribution of p27-PPE36 in sera of pulmonary tuberculosis patients and in sera from healthy control subjects by enzyme-linked immunosorbent assay (ELISA). We detected in the sera of affected individuals a significant increase of IgA antibody response, a no significant augmentation of IgM response, a complete lack of IgG2, 3, and 4 responses and a weak IgG1 response in a few subjects.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium tuberculosis, PPE36 protein, Serodiagnosis, ELISA
Plan
Vol 93 - N° 2
P. 189-191 - mars 2013 Retour au numéro
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