Tuberculosis skin test, but not interferon-γ-releasing assays is affected by BCG vaccination in HIV patients - 06/03/13
Corresponding author. Tel.: +49 69 6301 87779; fax: +49 69 6301 6309.Summary |
Objective |
Of this study was to compare the results of tuberculin skin test (TST) with two interferon-γ releasing-assays (IGRA) in a cohort of HIV positive patients, to analyze impact of prior Bacille-Calmette–Guérin (BCG)-vaccination.
Methods |
Prospective cross sectional study, enrolling only asymptomatic adult HIV infected outpatients from a large German University hospital clinic. All participants were simultaneously tested for latent tuberculosis infection (LTBI) by QuantiFERON-TB Gold, T-SPOT.TB and TST. Only individuals with available definite results (positive/negative, indeterminates excluded) from all three test systems and recalling BCG-vaccination status by interview questionnaire were evaluated.
Results |
From 286 study participants, 133 were evaluable; BCG-vaccination history was positive for 18 individuals, and negative for 115. The proportion of individuals with a positive TST was significantly higher for vaccinated (n = 6, 33.3%) than for unvaccinated individuals (n = 13, 11.3%, p = 0.013). There were no significant differences in the proportion of patients with CDC stage C, origin from a TB endemic country or in the CD4 count between the two groups.
Conclusion |
TST but not IGRAs interfered significantly with prior BCG vaccination in a cohort of HIV infected individuals from a low prevalence TB country. Therefore IGRA should preferentially be used for LTBI-testing in BCG-vaccinated adult HIV-patients.
Le texte complet de cet article est disponible en PDF.Keywords : BCG-vaccination, Latent tuberculosis infection, Tuberculin skin test, Interferon gamma releasing-assay, Human immunodeficiency virus (HIV)
Plan
Vol 66 - N° 4
P. 376-380 - avril 2013 Retour au numéro
Article précédent
- Enhanced serodiagnostic utility of novel Mycobacterium tuberculosis polyproteins
- Xiaoyan Feng, Bingshui Xiu, Kun Chen, Xiqin Yang, Hongtao Zhang, Jun Yue, Yaoju Tan, Hongmin Li, Russell A. Nicholson, Albert W. Tam, Ping Zhao, Li Zhang, Jing Liu, Xiaoguo Song, Guohua Wang, Heqiu Zhang
- Interferon-γ release assays versus tuberculin skin test for targeting people for tuberculosis preventive treatment: An evidence-based review
- Laura Muñoz, Miguel Santin
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?