Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children - 27/02/13
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Abstract |
Background |
Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.
Objectives |
We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children.
Methods |
The Columbia Center for Children’s Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years.
Results |
Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively).
Conclusions |
This is the first report of an association between postnatal urinary BPA concentrations and asthma in children.
Le texte complet de cet article est disponible en PDF.Key words : Bisphenol A, asthma, wheeze, children, exhaled nitric oxide, IgE, cohort study
Abbreviations used : BPA, Feno, OR, QC
Plan
Supported by the National Institute of Environmental Health Sciences (RC2ES018784, R01ES014393, P30ES009089, R01ES08977, R01ES013163, and PO1ES09600), the US Environmental Protection Agency (R827027, RD832141, and RD834509), the John and Wendy Neu Family Foundation, the Blanchette Hooker Rockefeller Fund, New York Community Trust, the Educational Foundation of America, and the Millstream Fund. The findings expressed in this article are the opinions of the authors and do not necessarily reflect the official opinion of the Centers for Disease Control and Prevention. |
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Disclosure of potential conflict of interest: K. M. Donohue has received research and travel support from the National Institutes of Health (NIH), is employed by Columbia University, and has received travel support from the Alpha-1 Foundation. R. L. Miller has received research support from the NIH and the US Environmental Protection Agency (EPA). M. S. Perzanowski has received research support from the NIH and has received travel support from Indoor Biotechnology. L. A. Hoepner has received research support from the National Institute of Environmental Health Sciences. S. Canfield has received research support from the NIH and EPA and has received travel support from the NIH. D. Resnick has received research support from the NIH. R. M. Whyatt has received research and travel support from the NIH and is employed by Columbia University. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 131 - N° 3
P. 736 - mars 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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