Maternal Residential Atrazine Exposure and Risk for Choanal Atresia and Stenosis in Offspring - 26/02/13
Reprint requests: Philip J. Lupo, PhD, University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030.Abstract |
Objective |
To assess the relationship between estimated residential maternal exposure to atrazine during pregnancy and the risk for choanal atresia or stenosis in offspring.
Study design |
Data for 280 nonsyndromic cases and randomly selected, population-based controls delivered between 1999 and 2008 were obtained from the Texas Birth Defects Registry. County-level estimates of atrazine levels obtained from the US Geological Survey were assigned to cases and controls based on maternal county of residence at delivery. Unconditional logistic regression was used to assess the relationship between maternal residential atrazine exposure and the risk for choanal atresia or stenosis in offspring.
Results |
Compared with offspring of mothers with low levels of estimated residential atrazine exposure, those with high levels had nearly a 2-fold increase in risk for choanal atresia or stenosis (aOR, 1.79; 95% CI, 1.17-2.74). A significant linear trend was also observed with increasing levels of atrazine exposure (adjusted P = .002).
Conclusion |
A link between maternal exposure to endocrine disruptors, such as atrazine, and the risk of choanal atresia is plausible based on previous findings. Our results lend further support to this hypothesis.
Le texte complet de cet article est disponible en PDF.Keyword : BPA, USGS
Plan
| Supported in part by the Centers for Disease Control and Prevention (CDC)-funded Texas Center for Birth Defects Research and Prevention (5U01DD000494) through a cooperative agreement with Texas Department of State Health Services (DSHS), as well as the Title V Office of Texas DSHS. The contents of this study are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. The authors declare no conflicts of interest. |
Vol 162 - N° 3
P. 581-586 - mars 2013 Retour au numéro
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