Genetic variation in the Toll-like receptor signaling pathway is associated with childhood asthma - 30/01/13
Doi : 10.1016/j.jaci.2012.10.061
Ramesh Chandra Pandey, MS a, Sven Michel, MSc a, Riccardina Tesse, MD a, Aristea Binia, PhD a, Michaela Schedel, PhD a, Liming Liang, PhD b, Norman Klopp, PhD c, d, Andre Franke, PhD e, Andrea von Berg, MD f, Albrecht Bufe, MD g, Ernst Rietschel, MD h, Andrea Heinzmann, MD i, Otto Laub, MD j, Burkhard Simma, MD k, Thomas Frischer, MD l, Jon Genuneit, MD m, Thomas Illig, PhD c, d, Michael Kabesch, MD a, n
a Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
b Department of Epidemiology, Harvard School of Public Health, Boston, Mass
c Research Unit of Molecular Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany
d Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
e Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany
f Research Institute for the Prevention of Allergic Diseases, Children’s Department, Marien-Hospital, Wesel, Germany
g Department of Experimental Pneumology, Ruhr-University, Bochum, Germany
h University Children’s Hospital, University of Cologne, Cologne, Germany
i University Children’s Hospital, Albert Ludwigs University, Freiburg, Germany
j Kinder- und Jugendarztpraxis Laub, Rosenheim, Germany
k Children’s Department, University Teaching Hospital, Landeskrankenhaus Feldkirch, Feldkirch, Austria
l University Children’s Hospital Vienna, Vienna, Austria
m Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
n University Children’s Hospital Regensburg (KUNO), Department of Pediatric Pneumology and Allergy, Regensburg, Germany
| This work was funded by the German ministry of education and research (BMBF) as part of the National Genome Research Network (NGFN), with grant NGFN 01GS0810, and by the European Commission as part of the GABRIEL (a multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community), contract no. 018996 under the Integrated Program LSH-2004-1.2.5-1. R.C.P. is supported by a research fellowship from the GRK1441 (Allergy) program of Deutsche Forschungsgemeinschaft (DFG) and was supported by the PhD program “Molecular Medicine,” Hannover Biomedical Research School (HBRS). |
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| Disclosure of potential conflict of interest: A. von Berg has received payment for lectures from the Nestlé Nutrition Institute. E. Rietschel is on the board and has received payment for lectures from Merck Sharpe & Dohme. T. Frischer has received payment for lectures from Abbott. M. Kabesch has received grants from the European Union, the German Ministry of Education and Research, and the German Research Foundation and has received payment for lectures from the European Respiratory Society, the European Academy of Allergology and Clinical Immunology, the American Thoracic Society, Novartis, and GlaxoSmithKline. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2012
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 131 - N° 2
P. 602-605 - février 2013 Retour au numéro
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