The multifunctional role of filaggrin in allergic skin disease - 30/01/13
Corresponding author: Alan D. Irvine, MD, FRCPI, Department of Paediatric Dermatology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.Abstract |
Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in the filaggrin gene are the most significant known genetic risk factor for the development of atopic dermatitis. Mutations in the human filaggrin gene (FLG) also confer risk for the associated allergic diseases of food allergy, asthma, and allergic rhinitis. These discoveries have highlighted the importance of skin barrier function in the pathogenesis of atopic diseases and have motivated a surge in research characterizing the filaggrin-deficient skin barrier and its consequences. In this review we discuss the mechanisms through which mutations in this protein contribute to the pathogenesis of atopic dermatitis and associated atopic conditions. We focus on recent human and murine discoveries characterizing the filaggrin-deficient epidermis with respect to biophysical, immunologic, and microbiome abnormalities.
Le texte complet de cet article est disponible en PDF.Key words : Filaggrin, atopy, dermatitis, eczema, IL-1β, skin barrier, transepidermal water loss
Abbreviations used : AD, ADFLG, ADNON-FLG, CNV, FLG, Flg, FLG+/+, FLG+/−, FLG−/−, IsdA, NLR, NLRP3, NMF, OR, OVA, PCA, SEB, SC, SpA, TEWL, TLR, TSLP, UCA
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| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, and William T. Shearer, MD, PhD |
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| Supported by the National Children’s Research Centre, Dublin. |
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| Disclosure of potential conflict of interest: A. D. Irvine has consultant arrangements with Janssen and Galderma, has received grants from the Wellcome Trust and the National Children’s Research Centre, has received payment for lectures from Janssen, and has received royalties from Wiley. M. A. McAleer declares no relevant conflicts of interest. |
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| Terms in boldface and italics are defined in the glossary on page 281. |
Vol 131 - N° 2
P. 280-291 - février 2013 Retour au numéro
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