Relationship Between Mean Platelet Volume and Coronary Blood Flow in Patients with Atrial Fibrillation - 16/01/13
, Weiyi Mei, MD b, 1, 2 , Chufan Luo, MD a, ⁎ , Ming Long, MD a, 2 , Xun Hu, MD a, 2 , Yong Huang, PhD c , Yuantao Hao, PhD c , Zhimin Du, MD a, 2 
Corresponding author at: Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou 510080, China. Tel.: +86 20 87755766x8137; fax: +86 20 87750632.Résumé |
Introduction |
Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary artery disease (CAD).
Methods |
This observational study enrolled 185 AF patients and 189 control subjects, all with angiographically documented normal coronary arteries. MPV was measured at baseline and mean TFC was assessed after diagnostic coronary angiography.
Results |
The MPV was 9.95±1.32 in the AF group and 9.02±1.16 in the control group (p<0.001). In AF patients, MPV was significantly correlated with mean TFC (r=0.419, p<0.001), AF duration (r=0.407, p<0.001), AF classification (r=0.378, p<0.001), systemic hypertension (r=0.165, p=0.024), diabetes mellitus (r=0.233, p=0.001), left ventricular ejection fraction (r=−0.347, p<0.001), and baseline use of diuretics (r=0.177, p=0.016). In linear regression analysis, mean TFC, left ventricular ejection fraction and diabetes mellitus were found to be independently associated with MPV (p<0.001, p=0.028 and p=0.045 respectively).
Conclusion |
Mean platelet volume seems to be independently associated with coronary blood flow in patients with atrial fibrillation in the absence of obstructive coronary artery disease.
Le texte complet de cet article est disponible en PDF.Abbreviations : AF, CAD, LAD, LCX, MPV, RCA, TFC, TIMI
Keywords : Atrial fibrillation, Mean platelet volume, TIMI frame count, Coronary flow
Plan
Vol 22 - N° 1
P. 43-49 - janvier 2013 Retour au numéro
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