Extraluminal Atherosclerosis: An Under-recognised Finding in Human Aortocoronary Venous Bypass Grafts - 16/01/13
Résumé |
Background |
Coronary artery bypass grafting (CABG) is commonly compromised by graft atherosclerosis. Histopathologic studies confirm various forms of atherosclerosis, including positively remodelled lesions in native coronary arteries but there are no histopathologic reports of extraluminal atherosclerosis in vein grafts.
Methods |
We prospectively investigated the histopathologic presence and pattern of extraluminal atherosclerosis in human old vein grafts in a two-year interval among patients undergoing redo-CABG at three university hospitals in Tehran. We separately documented clinical and angiographic findings.
Results |
We evaluated 100 segments from 20 human old vein grafts obtained during the redo CABG. All but four segments demonstrated some degrees of luminal narrowing. Luminal atherosclerotic plaques were detectable in 61 segments. We detected extraluminal atheroscleoris in seven segments. Mean vessel wall thickness was greater in segments containing extraluminal plaques (1.41±0.26mm versus 0.91±0.04mm, P=0.008). Angiographic findings had a modest correlation with presence or absence of luminal atheromatous lesions (Spearman’s rho: 0.331, P=0.007). Angiographic degree of stenosis could not predict the presence of positively remodelled atherosclerotic plaques (Spearman’s rho: −2.21, P=0.073).
Conclusion |
Previous studies suggested positive remodelling in vein grafts. Out study provides histopathologic evidence on extraluminal atherosclerosis in human aortocoronary vein grafts.
Le texte complet de cet article est disponible en PDF.Abbreviations : CABG, HPF, IVUS, NRITLD
Keywords : Atherosclerosis, Vein, Graft, Extraluminal, Positive remodelling
Plan
This study was supported by a research grant from Shahid Beheshti University of Medical Sciences High Research Council. |
Vol 22 - N° 1
P. 19-24 - janvier 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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