Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents - 21/12/12
Reprints: Piers C. A. Barker, MD, Duke University Medical Center, 7506 Hospital North, DUMC Box 3090, Durham, NC 27710Résumé |
Objective |
The importance of maternal autoantibody levels in congenital heart block and elucidation of maternal factors that may reduce disease burden require further clarification.
Study Design |
Pregnancies complicated by maternal anti-Ro antibodies from 2007 through 2011 were retrospectively reviewed.
Results |
In all, 33 women were followed up throughout pregnancy. Semiquantitative maternal anti-La levels were significantly higher in pregnancies complicated by fetal heart block of any degree (median difference, 227.5; P = .04), but there was no difference in maternal anti-Ro levels. In all, 94% of fetuses maintained normal conduction when the mother was treated with hydroxychloroquine or daily prednisone therapy throughout pregnancy, compared to 59% in the untreated group (odds ratio, 0.1; P = .04).
Conclusion |
Pregnancies complicated by fetal heart block did not have higher levels of maternal anti-Ro antibodies. Maternal anti-La level may be a useful predictor of fetal heart block. Maternal treatment with either hydroxychloroquine or daily low-dose prednisone throughout pregnancy may provide a protective effect.
Le texte complet de cet article est disponible en PDF.Key words : autoantibodies, congenital heart block, fetal echocardiography, prevention
Plan
| The authors report no conflict of interest. |
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| Cite this article as: Tunks RD, Clowse MEB, Miller SG, et al. Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents. Am J Obstet Gynecol 2013;208:64.e1-7. |
Vol 208 - N° 1
P. 64.e1-64.e7 - janvier 2013 Retour au numéro
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