Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV - 07/12/12
, Samreen Ijaz b, Neesha Rockwood a, Simon P. Farnworth a, Emma Devitt a, Mark Atkins c, Richard Tedder b, Mark Nelson a
Corresponding author. Chelsea and Westminster Hospital NHS Foundation Trust, HIV & Sexual Health Department, 369 Fulham Road, London SW10 9NH, United Kingdom. Tel.: +44 2087468000; fax: +44 2088467582.Summary |
Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatitis E, Liver, Transaminitis, HIV, Immunosuppression, Pegylated interferon
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Vol 66 - N° 1
P. 103-106 - janvier 2013 Retour au numéro
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