Pro-inflammatory cytokines IL6, TNF-⍺, IL1β, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis - 23/11/12
, L.V. Harper b, A.B. Vernallis b, S. Lang c, P.A. Lambert b, A.M. Ranasinghe d, T.S.J. Elliott e
Corresponding author.Summary |
Objective |
To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).
Patients and methods |
Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-⍺ (TNF-⍺), interleukin 1-β (IL1β), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).
Results |
Serum levels of IL6, IL1β and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-⍺ and LBP were not elevated.
Conclusion |
Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
Le texte complet de cet article est disponible en PDF.Keywords : Infective endocarditis, Inflammatory markers, Cytokines, Acute phase proteins
Plan
Vol 55 - N° 3
P. 220-225 - septembre 2007 Retour au numéro
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